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38- "Strange disease..." "Etrange mal..."

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Unknown syndrome (for us)

"Black syndrome" :
Common but unknown. Generalized disease. Sub acute or chronic evolution. Never resolves. Usually, general condition is not really effected. But patients are more subject to "Steven Johnson" and "Moult syndrome". Male and females. Sometimes induce by a drug (sulfas, TB treatment...) but often impossible for us to find the cause... Probably allergy? Probably multifactorial? Patients present the syndrome without having had any new drugs in months... and sometimes without taking any medicine at all... (see protocol "06-allergy"& " 30-skin" as well)

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"Moult syndrome" :

Common but unknown. Dry moult of skin. Large areas of skin peel off.

In the "moult syndrome", the face is never affected while the palms of hands and soles of feet are always involved. Distribution of lesions is always symmetrical. Unlike erythroderma, not all areas of the body are affected. Crusts are thicker than with erythroderma. General conditions are not affected (no fever, nor other infectious signs...). Disease resolves without specifical treatment and relapse often... Males are more affected than females..

Dermatologists say that the cause of disease could be a soft species of staphylococcus (SSSSS). BUT it seems that patient can be affected by the syndromr when taking cloxa or genta. Our recent experience causes us think that this common syndrome (in our ward) can also be an allergic reaction (We had a patient who developed the "moult syndrome" two times, each time a few days after a massive allergic reaction...) It is not always possible to invoque a drug allergy...

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